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pentobarbital will minimize the level or effect of netupitant/palonosetron by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Netupitant is especially metabolized by CYP3A4; stay clear of use in individuals who're chronically making use of a strong CYP3A4 inducerIn yrs earlier, barbiturates were being a